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The most potent compound among the 3-imidazolylindoles,prepared by a van Leusen multicomponent reaction, has an IC50 of 15 nM forMDM2 in an FP binding assay and an IC50 of 1.32 ?M for MDMX in a TR-FRETbinding assay. Its thickness varies in different parts of the bone. It affects males more often than females (3:1 ratio)and is rare in people of African descent. Breast-conserving surgical therapy (lumpectomy) plus radiotherapy is thestandard of care for invasive disease. For instance, in within-subjects designs, in which there aremany repeated observations and many data points, small samples have been used and arequite adequate

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The superior vesical arteries(lateral umbilical ligaments) are divided at each side of the bladder. The p53mutants exhibited a range of radiosensitivities [30].

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